This hotel is nestled in Siena’s historical center, and is just a short distance from both the Piazza del Campo and the Dome. There are numerous other points of interest, restaurants, osterias, trattorias, and public transportation hubs located within close proximity of the Piccolo Hotel Il Palio as well. Both a bus terminal and train station can be found within walking distance of the Piccolo Hotel Il Palio. A parking area can be found approximately 300 meters from the hotel.

Each of the 26 guestrooms in the Piccolo Hotel Il Palio is furnished in a simple style and contains a selection of in-room amenities to help make each guest more comfortable. Some of the available amenities include satellite TV, mini-bars, refrigerators, direct-dial phones, desks, and hairdryers.

The Piccolo Hotel Il Palio was once a monastery known as the Convento dei Tre Mori; the building was later converted into a hotel around the 15th century. An authentic Italian breakfast can be enjoyed in the coffee bar in front of the hotel each morning, and is included in the rate. The staff at the front desk can give advice about various attractions that tourists may wish to visit, and directions on how to get there.